Antioxidants and Antihyperlipidemia Test of Ethanol Extract of Indonesian Plant Sambang Getih Leaves (Hemigraphis Bicolor Boerl.) In Hyperlipidemia Mice

AIM: Sambih getih leaves (SGL) contain flavonoids acting as an antioxidant and antihyperlipidemia. The purpose of this study is to determine the activity antihyperlipidemia effect Ethanol Extract Sambang Getih Leaves (EESGL). METHODS: EESGL was tested for in vitro vivo. Antihyperlipidemia test SGL done by looking at blood lipid parameters, that are total cholesterol, triglyceride, low-density lipoprotein (LDL), high-density (HDL). 2,2-diphenyl-1-picrylhydrazyl (DPPH) atorvastatin showed Inhibition Concentration (IC50) values 24.15 86.75 ppm. In vivo divided into six groups: Normal, negative, positive (atorvastatin), low dose 487.5, medium 975, high 1950 mg/kg groups. RESULTS: Measurements Malondialdehyde (MDA) plasma levels mice on groups 21st day were 1.91 ± 0.51; 5.86 0.57; 2.18 0.55; 4.33 0.16; 3.08 0.06; 1.82 0.19 nmol/mL. Superoxide Dismutase (SOD) each group 193.29 3.36; 89.41 2.84; 192.46 4.25; 175.53 1.71; 191.53 3.34; 192.83 2.88 U/mL. Results cholesterol level low, medium, 62.16%, 40.50%, 48.55%, 59.52%. decrease triglyceride 48.94%, 27.78%, 34.27%, 54.02%. LDL 82.77%, 57.43%, 65.18%, 77.67%. Increased HDL 20.24%, 17.94%, 17.08%, 17.84%. CONCLUSION: Based results obtained, it can be concluded have but not good atorvastatin.